Buy liquid ketamine online from our trusted online shop. Ketamine (brand name: Ketalar) is a dissociative injected anesthetic (blocks sensory perception) that has been available by prescription in the U.S. since the 1970s for human and veterinary uses. Esketamine (Spravato), the S-enantiomer of racemic ketamine, was approved in 2019 for treatment-resistant depression and is approved for use in depressed patients with acute suicidal ideation or behavior.

Dissociative drugs can lead to distortion of sights, colors, sounds, self, and one’s environment. Ketamine is available in a clear liquid or off-white powder form for intravenous injection or as a nasal spray. Examples of other dissociative drugs include phencyclidine (PCP) and dextromethorphan (DXM).

In the U.S., ketamine is classified as a schedule III drug under the DEA Controlled Substances Act; however, it is not classified as an opioid (narcotic) or barbiturate.

Why is Ketamine Used Medically?

• Ketamine can provide pain relief and short-term memory loss (for example, amnesia of a medical procedure).
• Ketamine, through blocking at the N-methyl-D-aspartate (NMDA) site, has rapid action in controlling symptoms of depression and acute suicidal ideation.

Pharmacology of Ketamine

Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, and it blocks HCN1 receptors. However, at higher doses it may also bind to the opioid mu and sigma receptors. It disrupts the neurotransmitter (brain chemical) glutamate. Glutamate is involved with learning, memory, emotion, and pain recognition. It can exhibit sympathomimetic activity which can lead to rapid heart rate and elevated blood pressure.

It is related to phencyclidine (PCP), but has less than 10% of the potency of pure PCP.

This agent is a lipid soluble compound, has an initial rapid distribution and large volume of distribution, with a half-life of 10 to 15 minutes.

How Quickly Does Ketamine Work?

• An injection yields a quick response, with effects occurring in seconds to minutes.
• “Snorting” leads to effects in roughly 5 to 15 minutes (this is the most common method of abuse).
• Oral consumption requires between 5 and 30 minutes.

Sensations the user may seek include floating, stimulation and visual effects.

High doses may dangerously reduce breathing, lead to muscle spasms or weakness, dizziness, balance difficulty, impaired vision, slurred speech, nausea and vomiting, and severe confusion.